Development of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavity

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dc.authoridAyça Bal Öztürk / 0000-0002-6502-528Xen_US
dc.authoridZeynep Püren Akgüner / 0000-0002-9626-1605
dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorscopusidZeynep Püren Akgüner / 57205403842
dc.authorwosidAyça Bal Öztürk / M-4472-2018
dc.authorwosidZeynep Püren Akgüner / CBX-7589-2022
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorYaşayan, Gökçen
dc.contributor.authorPüren Akgüner, Zeynep
dc.contributor.authorYarımcan, Filiz
dc.contributor.authorAlarçin, Emine
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2021-12-03T12:02:18Z
dc.date.available2021-12-03T12:02:18Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Enstitüsü, Kök Hücre ve Doku Mühendisliği Ana Bilim Dalıen_US
dc.description.abstractIn this study, modified kappa-carrageenan/pectin hydrogel patches were fabricated for treatment of buccal fungal infections. For this purpose, kappa-carrageenan-g-acrylic acid was modified with different thiolated agents (L-cysteine and 3-mercaptopropionic acid), and the thiol content of the resulting modified kappa-carrageenan was confirmed by elemental analyzer. Then, the hydrogel patches were fabricated, and characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, ex vivo mucoadhesion test, and swelling behavior. Triamcinolone acetonide was added either directly or by encapsulating within the poly(lactic-co-glycolic acid) nanoparticles. The release amount of the drug from the directly loaded patch was 7.81 mg/g polymer, while it was 3.28 mg/g polymer for the encapsulated patch with the same content at 7 hr. The hydrogel patches had no cytotoxicity by cell culture studies. Finally, the drug loaded hydrogel patches were demonstrated antifungal activity against Aspergillus fumigatus and Aspergillus flavus. These results provide that the novel modified kappa-carrageenan and pectin based buccal delivery system has promising antifungal property, and could have advantages compared to conventional buccal delivery systems.en_US
dc.identifier.citationÖzkahraman, B., Özbaş, Z., Yaşayan, G., Akgüner, Z. P., Yarımcan, F., Alarçin, E., & Bal-Öztürk, A. (2021). Development of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavity. Journal of biomedical materials research. Part B, Applied biomaterials, 10.1002/jbm.b.34958. Advance online publication.en_US
dc.identifier.doi10.1002/jbm.b.34958en_US
dc.identifier.pmid34846796en_US
dc.identifier.scopus2-s2.0-85120158755en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/jbm.b.34958
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2302
dc.identifier.wosWOS:000723711600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPüren Akgüner, Zeynep
dc.institutionauthorBal Öztürk, Ayça
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biomedical Materials Research Part B: Applied Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntifungal Activityen_US
dc.subjectBuccal Drug Deliveryen_US
dc.subjectThiolated Kappa-Carrageenanen_US
dc.subjectTriamcinolone Acetonideen_US
dc.titleDevelopment of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavityen_US
dc.typeArticleen_US

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