Evaluation of cerebral blood flow alterations and acute neuronal damage due to water-pipe smoking
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayincilik
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Although water-pipe smoking is a great public health problem, data regarding the acute and chronic effects and the degree of toxin exposure are limited. While water pipe-related malignancy, pulmonary. infectious, cardiac effects, infertility, and biological effects have been described in a meta-analysis. there are no studies in the literature about its neurologic effects. Aims: To evaluate water pipe-related acute neurological effects and cerebral blood flow through transcranial Doppler ultrasonography and serum S100 calcium binding protein calcium binding protein level measurements. Study Design: Prospective observational study. Methods: Vital signs and baseline carboxyhemoglobin and S100 calcium binding protein levels, cerebral flood changes with transcranial Doppler ultrasound were evaluated and recorded before and after water-pipe smoking. Results: The mean age of the 31 volunteers was 30.61 (+/- 5.67) years and 24 of them (77.42%) were male. A statistically significant difference was determined in heart rate, oxygen saturation, systolic and diastolic arterial pressure values before and after water-pipe smoking (p<0.001, p=0.035, p=0.009, p=0.021, respectively). Mean carboxyhemoglobin level was 2.68% (+/- 1.68) before, 14.97% (+/- 4.83) after water-pipe smoking (p<0.001). The S100 calcium binding protein level was 25.05 mu/mL (+/- 8.34) at the beginning, 40.71 mu/mL (+/- 14.06) after water-pipe smoking (p<0.001). An increase was determined in peak, and median middle, anterior and posterior cerebral artery blood flow rates, and a decrease was determined in both the pulsatility index and resistivity index values after water-pipe smoking using transcranial Doppler ultrasound. Conclusion: Cerebral vasodilation develops due to the increase in cerebral blood flow rate and the decrease in pulsatility index, resistivity index values, and the elevation in carboxyhemoglobin, S100 calcium binding protein level indicates that water-pipe smoking leads to neuronal damage in the acute period.
Açıklama
Anahtar Kelimeler
Acute Injury, Carboxyhemoglobin, Cerebral Blood Flow, S100 Proteins, Water Pipe Smoking
Kaynak
Balkan Medical Journal
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
36
Sayı
2
Künye
Karakayalı, O., Utku, U., & Yılmaz, S. (2019). Evaluation of Cerebral Blood Flow Alterations and Acute Neuronal Damage due to Water-Pipe Smoking. Balkan medical journal, 36(2), 106.
